Combination Pravastatin and Valsartan Treatment have Additive Beneficial Effects to Simultaneously Improve Both Metabolic and Cardiovascular Phenotypes beyond that of Monotherapy with Either Drug In Patients with Primary Hypercholesterolemia
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Word Counts; 200 Total Word Counts; 2126 Running Title: Running Title: Beneficial Pravastatin/Valsartan Combination Therapy Page 1 of 22 Diabetes Diabetes Publish Ahead of Print, published online July 17, 2013
منابع مشابه
Combination Pravastatin and Valsartan Treatment Has Additive Beneficial Effects to Simultaneously Improve Both Metabolic and Cardiovascular Phenotypes Beyond That of Monotherapy With Either Drug in Patients With Primary Hypercholesterolemia
Statin and angiotensin II type 1 receptor blocker therapy improves endothelial dysfunction using distinct mechanisms. We evaluated simultaneous vascular and metabolic responses to pravastatin and valsartan therapy, alone or in combination, in hypercholesterolemic patients. Forty-eight hypercholesterolemic patients (23 had metabolic syndrome) were given pravastatin 40 mg and placebo, pravastatin...
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AIMS Ramipril and candesartan have distinct mechanisms of action to improve endothelial function. Therefore, we hypothesized that combination therapy has additive beneficial effects to simultaneously improve endothelial dysfunction and adipocytokine profiles in patients with hypertension. METHODS AND RESULTS Thirty-four patients were given ramipril 10 mg and placebo, ramipril 10 mg and candes...
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متن کاملAdditive Beneficial Effects of Valsartan Combined with Rosuvastatin in the Treatment of Hypercholesterolemic Hypertensive Patients
BACKGROUND AND OBJECTIVES We compared the efficacy and safety of valsartan and rosuvastatin combination therapy with each treatment alone in hypercholesterolemic hypertensive patients. SUBJECTS AND METHODS Patients who met inclusion criteria were randomized to receive 1 of the following 2-month drug regimens: valsartan 160 mg plus rosuvastatin 20 mg, valsartan 160 mg plus placebo, or rosuvast...
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تاریخ انتشار 2013